Indira College of Commerce and Science is having tie-ups with the various renowned industries, universities, institutions and social organizations by signing the MOUs. 

This helps in knowledge acquisition through training programs in the area of IT, commerce and management, to learn practical approaches towards the subject, to get hands-on training, learning with internship projects and placements.  Students get certification for better career prospects. Some of the key Organizations are Quick Heal Technologies, Asia Pacific University - Kuala Lumpur(Malaysia), I-Medita, Bombay Stock Exchange Institute Ltd, Synergy University Moscow(Russia) and Elite School of Professionals.

This not only helps in technical and management, but also helps in social outreach of students. The Adar Poonawalla Clean City Initiative Linkage helps to engross students for community reach out and inculcate cleanliness in the environment. Environment Conservation Association (ECA), helps students for survey projects.

The initiative supports faculties by engaging in faculty exchange programs and participation in various activities of research, jointly organising seminars, workshops and conferences. Some of the significant institutes are KES Pratibha College of Commerce and Computer Studies, Dr. D.Y.Patil Arts, Science and Commerce college.